As cancer grows, phenotypic changes, often manifested in microscopic structural changes, are expressed in more and more of the tissue, eventually resulting in palpable lesions. One key question is at what scale changes in mechanical properties are expressed, the tissue ‘mechano-type’. This project aims to establish quantitative and clinically-validated relationships between mechano- and pheno-types of prostate cancers in face of structural confounders such as benign prostate hyperplasia (BPH) and isolating disease-specific from patient-specific variations.

Team

Principal Investigator: Yuhang Chen (HWU)

Co-Investigators: Daniel Good (NHS Lothian, University of Edinburgh) and Bob Reuben (HWU)

Funding

Funded by Melville Trust for Cure and Care of Cancer.