This project proposes to make critical steps forward in bridging the gap between the advances in in vitro tissue engineering and its ultimate goal of ‘in vivo tissue regeneration’ by giving it an additional dimension of vitality, i.e. design optimisation of scaffolds subject to tissue-specificity and patient-specificity. The approach taken here is to establish a design optimisation framework that considers different tissue environment, the underlying engineering challenges of scaffolding in vivo, and the fluid and solid mechanics problems involved, using state-of-the-art computational tools including structural optimisation and inverse homogenisation.

Team

Principal Investigator: Yuhang Chen

Funding

Funded by Engineering and Physical Sciences Research Council (EPSRC).

A more recent pilot project was funded by EPSRC 4MD programme grant 
PI: Bob Reuben; co-I: Yuhang Chen, Duncan Hand.